Keep Current with the Latest in Cell Biology Research

DDX18 Coordinates Nucleolus Phase Separation and Nuclear Organization to Control the Pluripotency of Human Embryonic Stem Cells

[Nature Communications] Researchers showed that the nucleolus-specific RNA helicase DDX18 was essential for maintaining the pluripotency of human embryonic stem cells. They revealed how nucleolar phase separation dynamics govern chromatin organization and cell fate.

Metabolic Rewiring in Skin Epidermis Drives Tolerance to Oncogenic Mutations

[Nature Cell Biology] To interrogate the cellular properties that determine cell-competition outcomes, researchers combined live imaging of the mutant mosaic epidermis with optical redox imaging, so as to determine intracellular metabolic states as the tissue adapted to oncogenic mutations.

Interplay of Chromatin Remodeling BAF Complexes in Mouse Embryonic and Epiblast Stem Cell Conversion and Maintenance

[Journal of Biological Chemistry] Scientists demonstrated that the LIF/STAT3 and Wnt signaling pathways, in conjunction with canonical BAF (cBAF) and PRC2 complexes, inhibited epiblast stem cells (EpiSCs) gene expression, thereby preventing ESCs from converting to EpiSCs.

Reconstitution of Pluripotency from Mouse Fibroblast through Sall4 Overexpression

[Nature Communications] Investigators reported that SALL4 alone, under an optimized reprogramming medium iCD4, was capable of reprogramming mouse fibroblasts into iPSCs. Mechanistically, SALL4 facilitated reprogramming by inhibiting somatic genes and activating pluripotent genes, such as Esrrb and Tfap2c.

A NOTCH3 Pathogenic Variant Influences Osteogenesis and Can Be Targeted by Antisense Oligonucleotides in Induced Pluripotent Stem Cells

[PLOS One] To determine the consequences of Lateral Meningocele Syndrome pathogenic variants in human cells and whether they can be targeted by antisense oligonucleotides, induced pluripotent NCRM1 and NCRM5 stem cells harboring a NOTCH36692-93insC insertion were created.

Advances in Engineering Myeloid Cells for Cell Therapy Applications

[ACS Synthetic Biology] Recent advancements in stem cell research have made it possible to differentiate human ESCs and induce pluripotent stem cells into various cell types, including myeloid cells, offering a promising new approach to generate myeloid cells for cell therapy.

Modeling GATA2 Deficiency in Mice: The R396Q Mutation Disrupts Normal Hematopoiesis

[Leukemia] While mutant mice exhibited mild defects in peripheral blood, they displayed significant hematopoietic abnormalities in the bone marrow, including a reduction in hematopoietic stem cell function and intrinsic biases toward specific stem cell subsets that differed from previous models of GATA2 loss.

High Frequency CCR5 Editing in Human Hematopoietic Stem Progenitor Cells Protects Xenograft Mice from HIV Infection

[Nature Communications] Scientists showed the application of CRISPR/Cas9 to achieve >90% CCR5 editing in human, mobilized hematopoietic stem progenitor cells, resulting in a transplant that underwent normal hematopoiesis, produced CCR5 null T cells, and rendered xenograft mice refractory to HIV infection.

Datopotamab Deruxtecan in Advanced or Metastatic Non–Small Cell Lung Cancer with Actionable Genomic Alterations: Results from the Phase II TROPION-Lung05 Study

[Journal of Clinical Oncology] The TROPION-Lung05 Phase II trial evaluated the safety and clinical activity of datopotamab deruxtecan in patients with advanced NSCLC with actionable genomic alterations progressing on or after targeted therapy and platinum-based chemotherapy.

Trastuzumab plus Pertuzumab Versus Cetuximab plus Irinotecan in Patients with RAS/BRAF Wild-Type, HER2-Positive, Metastatic Colorectal Cancer (S1613): A Randomized Phase II Trial

[Journal of Clinical Oncology] Investigators conducted a randomized Phase II trial to evaluate efficacy and safety of dual-HER2 inhibition against standard-of-care anti-EGFR antibody–based therapy as second/third-line treatment in HER2-positive metastatic colorectal cancer.

Neoadjuvant Chemoradiation With or Without PD-1 Blockade in Locally Advanced Rectal Cancer: A Randomized Phase II Trial

[Nature Medicine] Scientists evaluated the efficacy and safety of the radiation–immune checkpoint inhibitor combination in patients with locally advanced rectal cancer in a Phase II, randomized trial conducted in eight major colorectal cancer centers in Beijing.

A Phase II Trial of Anlotinib plus EGFR-TKIs in Advanced Non-Small Cell Lung Cancer with Gradual, Oligo, or Potential Progression After EGFR-TKIs Treatment (CTONG-1803/ALTER-L001)

[Journal of Hematology & Oncology] Anlotinib in combination with continuation of EGFR-tyrosine kinase inhibitors (TKIs) prolonged the clinical benefit of EGFR-TKIs, demonstrating favorable survival outcomes and manageable toxicity in NSCLC treated with EGFR-TKIs and had specific progression modes, such as gradual progression.

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